| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217175 | Tetrahedron | 2014 | 7 Pages |
Abstract
An attempt of preparing a carbocyclic LNA-analogue using different RCM-methods failed. However, a compound with a hemiacetal linker between the C2â² and the C4â²-positions was isolated and found to be a suitable substrate for making a conformationally restricted double-headed nucleoside. This contains two uracil nucleobases organized on a bicyclic skeleton and is locked in an N-type conformation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Surender Kumar, Signe Inglev Steffansen, Nanna Albæk, Poul Nielsen,