| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217176 | Tetrahedron | 2014 | 7 Pages |
Abstract
The synthesis of four possible stereoisomers of the spiroacetal core of the natural products cephalosporolides H and I and penisporolides A and B is described. The key steps involve the use of Sharpless asymmetric dihydroxylation to install the desired stereochemistry of the γ-lactone ring and an oxidative radical cyclisation to form the spiroacetal ring system.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Orla C. Finch, Daniel P. Furkert, Margaret A. Brimble,