| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217209 | Tetrahedron | 2013 | 5 Pages |
Abstract
A chemoselective method for the hydrosilylation of ketones has been developed, using the combination of triphenylsilane and a catalyst prepared from Ni(COD)2 and the simple N-heterocyclic carbene IMes. The most notable feature of this method is that free hydroxyls are largely unaffected, thus providing a simple one-step procedure for the conversion of hydroxyketones to mono-protected diols, wherein the protecting group is exclusively installed on the ketone-derived hydroxyl. The process is typically high yielding with both simple ketones and more complex hydroxyketone substrates.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marta L. Lage, Scott J. Bader, Kanicha Sa-ei, John Montgomery,