| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217239 | Tetrahedron | 2014 | 9 Pages |
Abstract
20-Hydroxytriptonide was synthesized from readily accessible l-abietic acid in 22 linear steps, which features a Barton reaction carried out under air atmosphere to install the C20-hydroxy group. Meanwhile, we also synthesized (5R)-5-hydroxytriptolide's probable metabolite product. Preliminary structure–activity relationship studies revealed that C20-angular methyl group might play a key role in maintaining the electronic properties of the whole molecule, which was essential for retaining the cytotoxic activity and might easily and inevitably be affected by the introduction of a new group.
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