Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217304 | Tetrahedron | 2013 | 11 Pages |
Abstract
A simple one-pot procedure for the stereoselective synthesis of Knoevenagel-type indoles is described. The method is based on the in situ reaction of indole iminium salts (four of them are fully characterized) with acyclic symmetrical and unsymmetrical active methylene reagents in the presence of triethylamine. In general, the overall yields are moderate to good. Some of relevant reaction parameters and steric effects affecting stereoselectivity are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Angelo Ranise, Francesco Lucchesini, Matteo Caviglia, Silvana Alfei, Andrea Spallarossa, Chiara Caneva,