Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217306 | Tetrahedron | 2013 | 8 Pages |
Abstract
A new diastereoselective pathway for the total synthesis of (+)-dexoxadrol, first asymmetric synthesis of (â)-epi-dexoxadrol and formal synthesis of conhydrine and (+)-lentiginosine is presented using commercially available (â)-pipecolinic acid. The key reactions utilized are Sharpless asymmetric dihydroxylation and Wittig reaction. The paper further describes the study of effect of protecting groups on dihydroxylation of a terminal olefin in piperidine ring system.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chinmay Bhat, Santosh G. Tilve,