| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217332 | Tetrahedron | 2013 | 8 Pages |
Abstract
Fluorescent adenine mimetics are useful tools for studying DNA, RNA and enzyme functions. Herein we describe the synthesis of eight 1-(purinyl)triazoles and two 4-(purinyl)triazoles utilizing the 1,4-regioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction as the key step. The fluorescence properties of five of the synthesized 1-(purinyl)triazoles are also presented. The five measured compounds displayed low quantum yields. The results, when compared to previously published data, suggest a high influence of the substitution pattern of the triazole on the fluorescence properties.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Itedale Namro Redwan, David Bliman, Munefumi Tokugawa, Christopher Lawson, Morten Grøtli,