| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217370 | Tetrahedron | 2013 | 9 Pages |
Abstract
Carboxylate assistance was key to success for highly efficient ruthenium-catalyzed direct ortho-arylations of tetrazolyl-substituted arenes with aryl halides and triflates in the absence of phosphine ligands. Thus, ruthenium(II) biscarboxylates allowed for C-H bond functionalizations with excellent chemo- and site-selectivities, which set the stage for an atom- and step-economical access to key angiotensin-II-receptor blockers. Mechanistic studies revealed the C-H bond metalation to be reversible, and were suggestive of a rate-determining reductive elimination.
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Chemistry
Organic Chemistry
Authors
Emelyne Diers, N.Y. Phani Kumar, Tom Mejuch, Ilan Marek, Lutz Ackermann,