| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217492 | Tetrahedron | 2013 | 10 Pages |
Abstract
A series of 20 novel racemic iodo-, bromo- and chlorolactones, possessing β-phenyl-γ-lactone or β-phenyl-δ-lactone framework, were synthesized from commercially available aromatic aldehydes in convenient five-step syntheses. Some of them showed noticeable cytotoxic effect against two cancer lines, Jurkat (human leukaemia) and D17 (canine osteosarcoma). The highest activity, comparable with carboplatin, was observed for cis-5-(1-iodoethyl)-4-(4′-isopropylphenyl)dihydrofuran-2-one against Jurkat cell line.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
