Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217661 | Tetrahedron | 2013 | 11 Pages |
Abstract
A short three-step synthesis of tetrasubstituted 3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles has been worked out. This relatively unknown heterobicyclic system is assembled from two carbonyl compounds, an amine, a hydrazine, and mercaptoacetic acid ester. These versatile starting materials allow the introduction of a broad range of alkyl, haloalkyl, cycloalkyl, aryl, and heteroaryl substituents into four different positions of the bicyclic scaffold. The efficiency of the synthesis route is proven by the fact, that two of the three steps are a multicomponent reaction or a cascade reaction, respectively, and that it can further be shortened to two consecutive one-pot processes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sophie Pelletier, Benjamin Pinson, Tomas Smejkal, Clemens Lamberth,