Article ID Journal Published Year Pages File Type
5217748 Tetrahedron 2013 6 Pages PDF
Abstract

A facile and efficient enantioselective route for the synthesis of d-ribo-phytosphingosine (1a) and sphinganine (1b) has been developed employing commercially available and cheap starting material trans-cinnamaldehyde 2. The synthetic strategy features the Sharpless kinetic resolution, regioselective epoxide opening and Wittig olefination as the key steps.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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