| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217749 | Tetrahedron | 2013 | 6 Pages |
Abstract
A one-pot base-mediated synthesis of 5-oxopyrrolidine-2-carboxamides was developed. The reaction of Baylis–Hillman bromides 1, primary amines 2, isocyanides 3 and arylglyoxals 4 produced the 5-oxopyrrolidine-2-carboxamides 6 in good yields via a tandem Ugi condensation and intramolecular substitution at room temperature in the presence of Cs2CO3.
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