| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217751 | Tetrahedron | 2013 | 5 Pages |
Abstract
The combination of a chiral diether ligand and a lithium benzyl(trimethylsilyl)amide is a powerful lithium amide reagent for asymmetric conjugate amination of enoate in a toluene solvent. The structure of the chiral diether-lithium amide complex in solution was analyzed by low-temperature NMR. 6Li NMR suggested the formation of a cyclic heterodimer. The stereochemical pathway is predictable based on the structure of the lithium amide-chiral diether complex.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yasutomo Yamamoto, Hiroyuki Nasu, Kiyoshi Tomioka,