Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217819 | Tetrahedron | 2013 | 5 Pages |
Abstract
A series of 1-aryl-5-trifluoromethyl (or difluoromethyl)-1,4,5-trisubstituted 1,2,3-triazoles were synthesized in high yield by a novel one-pot three-component reaction of arylboronic acids, sodium azide, and active methylene ketones, such as ethyl 4,4-difluoroacetoacetate or ethyl 4,4,4-trifluoroacetoacetate in the presence of Cu(OAc)2 and piperidine using a DMSO/H2O (10/1) mixture as solvent.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jian Zhang, Guanyi Jin, Senhan Xiao, Jingjing Wu, Song Cao,