Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217885 | Tetrahedron | 2013 | 10 Pages |
Abstract
Idraparinux, the fully O-sulfated, O-methylated, heparin-related pentasaccharide possessing selective factor Xa inhibitory activity, was prepared by two novel synthetic pathways. Each route was based on a 2+3 block synthesis utilizing the same l-iduronic acid-containing trisaccharide acceptor, which was glycosylated with either a glucuronide disaccharide donor or its non-oxidized precursor. The latter route, involving the oxidation of the glucose unit into d-glucuronic acid at a pentasaccharide level proved to be much more efficient, providing the target pentasaccharide in a reasonable overall yield.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mihály Herczeg, Erika MezÅ, László Lázár, Anikó Fekete, Katalin E. Kövér, Sándor Antus, Anikó Borbás,