Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217888 | Tetrahedron | 2013 | 10 Pages |
Abstract
Synthesis of 9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carbonitrile (1) or 6-oxo-6,7-dihydrothiazolo[4,5-h]quinazoline-2-carbonitrile (2) was reinvestigated with the ambition of varying the position of the thiazole ring linked to the quinazolin-4-one moiety, in order to synthesize two novel linear tricyclic 8-oxo-7,8-dihydrothiazolo[4,5-g]quinazoline-2-carbonitrile (3) and 8-oxo-7,8-dihydrothiazolo[5,4-g]quinazoline-2-carbonitrile (4). The routes described in this paper open the door to various substitutions and transformations for an access to libraries of potent biologically active heterocyclic compounds.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Damien Hédou, Rémi Guillon, Charlotte Lecointe, Cédric Logé, Elizabeth Chosson, Thierry Besson,