Catalyst-free esterification of alcohols using 2-acyl-4,5-dichloropyridazinones under microwave conditions

Efficient and green esterification is of great importance. In this work, we demonstrate the catalyst-free esterification of alcohols by their reaction with 2-acyl-4,5-dichloropyridazin-3(2H)-ones under microwave irradiation. Aliphatic and aromatic alcohols were converted into the corresponding esters in good to excellent yields under microwave irradiation in solvent or solvent-free conditions. It is noteworthy that the reaction is catalyst-free, atom-economic, and rapid and that the process is inexpensive.

Graphical abstractDownload full-size image