| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217908 | Tetrahedron | 2013 | 7 Pages |
Abstract
An efficient and convenient protocol for synthesis of 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones is described. The reaction of allyl (aryl/alkyl) carbamates with fluoroalkyl iodide initiated by sodium dithionite in aqueous acetonitrile resulted in adducts that undergoes a cyclization assisted by microwave irradiation to form 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones with high yields. It was also found that the products can be more efficiently formed via an AIBN-initiated one-pot addition-cyclization sequence from benzyl allyl(aryl/alkyl) carbamates and fluoroalkyl iodide.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bo Yang, Luyan Shi, JingJing Wu, Xiang Fang, Xueyan Yang, Fanhong Wu,