| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217934 | Tetrahedron | 2013 | 9 Pages |
Abstract
Synthesis and inhibitory activities against α-l-fucosidase of phenylalkyl-substituted polyhydroxypiperidines have been described. Among the newly synthesized compounds, 2,4,6-trichloro derivative (16q) showed very high inhibitory activity against α-l-fucosidase with IC50 value of 0.005 μM, and Ki values of 0.0011 μM, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tomoki Saka, Toru Okaki, Shohei Ifuku, Yukiko Yamashita, Kasumi Sato, Shota Miyawaki, Akiko Kamori, Atsushi Kato, Isao Adachi, Yasuhiro Tezuka, Peter G. Kiria, Osamu Onomura, Daishiro Minato, Kenji Sugimoto, Yuji Matsuya, Naoki Toyooka,