| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218025 | Tetrahedron | 2013 | 5 Pages |
Abstract
Two new 16-membered macrolactone-type polyketides, Tianchimycin A (1) and B (2), were isolated from the rare actinomycete Saccharothrix xinjiangensis NRRL B-24321, together with one known compound, swalpamycin B (3). The isolated compounds were structurally characterized using 1D and 2D NMR and MS techniques. The antimicrobial activities of 1-3 were determined against a panel of Gram-negative and Gram-positive bacteria including five hospital isolates from NHS Grampian. Compound 3 displayed moderate antibacterial activity against three MRSA clinical isolates and Enterococcus faecalis ATCC 29212.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoling Wang, Jioji Tabudravu, Marcel Jaspars, Hai Deng,