| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218052 | Tetrahedron | 2013 | 7 Pages |
Abstract
Most of the super-statins contain a CC double bond spacer between the heterocyclic and the chiral dihydroxycarboxylic moieties. The known drugs are E-geometric isomers, whereas very little is known about their Z-isomeric analogues. This study explains the unusual resonance line broadening observed in 1H NMR spectra of Z-isomeric rosuvastatin analogues at room temperature, which originates from dynamic exchange between different conformers. Conformational equilibria and intrinsic preferences of Z-isomeric rosuvastatin analogues provide valuable insight into conformational variability that is important for studying potential interactions within the binding site of the enzyme.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jan Fabris, Damjan Makuc, Zdenko Äasar, Janez Plavec,