Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218071 | Tetrahedron | 2013 | 6 Pages |
Abstract
An efficient tandem method for the annulation of 1-amino-1H-pyrrole-2-amides with various substituted benzaldehydes, heteroaryl aldehydes, alkyl aldehydes or even acetals, promoted by cupric chloride, to synthesize 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones is reported. This approach provides a useful method for constructing the privileged structure in medicinal chemistry. Electron-donating groups on both partners could accelerate the reaction.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yanhong Chen, Haoyue Xiang, Cun Tan, Yuyuan Xie, Chunhao Yang,