Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218074 | Tetrahedron | 2013 | 5 Pages |
Abstract
Three new clovane-related sesquiterpenoids, rumphellclovanes C-E (1-3), and a new natural clovane, clovan-2,9-dione (4), were isolated from a gorgonian coral Rumphella antipathies. The structures of clovanes 1-4 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Rumphellclovane C (1) was proven to be the first clovane-type sesquiterpenoid containing an ε-lactone moiety. A plausible biosynthetic pathway between clovanes 1 and 2 was proposed. Clovane 4 displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hsu-Ming Chung, Jui-Hsin Su, Tsong-Long Hwang, Jan-Jung Li, Jih-Jung Chen, Yung-Husan Chen, Yu-Chia Chang, Yin-Di Su, Yu-Hsin Chen, Lee-Shing Fang, Jyh-Horng Sheu, Wei-Hsien Wang, Ping-Jyun Sung,