Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218097 | Tetrahedron | 2013 | 5 Pages |
Abstract
Adiponectin secretion from the mature adipocytes plays beneficial roles in diabetes mellitus and atherosclerosis, thereby diminishing the risk of metabolic syndrome. From the marine sponge Xestospongia testudinaria, we isolated five new brominated acetylenic fatty acids, including testufuran A, together with 11 known acetylenic acids. Most of them stimulated differentiation of preadipocytes to adipocytes and the resulting differentiated cells secreted adiponectin, which exhibits preferable effects toward a suite of conditions in cardiovascular disorders.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takuya Akiyama, Kentaro Takada, Tsutomu Oikawa, Nobuyasu Matsuura, Yuji Ise, Shigeru Okada, Shigeki Matsunaga,