| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218101 | Tetrahedron | 2013 | 6 Pages |
Abstract
Enantioselective Michael addition reactions of malononitrile and cyanoesters to α,β-unsaturated 2-acylimidazoles can be achieved in water using a DNA-based catalyst consisting of double-stranded DNA and copper(II) complex. Quantitative conversions and good enantioselectivities (up to 84% ee) are obtained for a wide range of substrates. The UV-vis absorption and circular dichroism (CD) indicate that the copper(II) complex may interact with salmon testes DNA via minor groove binding.
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Related Topics
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Organic Chemistry
Authors
Yinghao Li, Changhao Wang, Guoqing Jia, Shengmei Lu, Can Li,