Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218108 | Tetrahedron | 2013 | 9 Pages |
Abstract
The synthesis of an advanced intermediate is described that could secure the polyoxygenated core of zaragozic acids and related natural products. The key strategy employs a two-step synthesis of the 3(2H)-furanone ring system by catalytic dihydroxylation-mercury(II)/acid-catalysed cyclisation with concomitant deprotection. The scope of the 3(2H)-furanone synthesis has been evaluated, and this ring system is shown to remain intact in multi-step reaction sequences. Access to novel, highly oxygenated 3(2H)-furanone derivatives has been achieved.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mehrnoosh Ostovar, Charles M. Marson,