| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218143 | Tetrahedron | 2013 | 6 Pages |
Abstract
Organocatalytic Michael–aldol–dehydration domino reaction of 3-(1-hydroxyethylidene)benzofuran-2(3H)-ones and enones catalyzed by Cinchona-based primary amine has been developed. The desired chiral spirocyclic benzofuranones were obtained in excellent stereoselectivities (dr>20:1 and up to 96% ee) and moderate to excellent yields (up to 98%).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
