| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218186 | Tetrahedron | 2013 | 8 Pages |
Abstract
Highly enantioenriched trans-2,3-disubstituted indolines have been prepared by Mitsunobu cyclodehydration of the amino alcohols obtained from (â)- or (+)-sparteine-mediated lithiation-substitution of ortho-alkyl substituted N-pivaloylanilines. Optimized cyclodehydration conditions are described, from which the combination of DEAD and PBu3 in CH3CN provides the best results.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyoung Hee Kang, Yelim Kim, Chan Im, Yong Sun Park,