| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218227 | Tetrahedron | 2013 | 6 Pages |
Abstract
Alkylation of 4,5-dihydroimidazoles at C-2 is accomplished using a double umpolung of the reactivity of that position, via sulfenylation of a nucleophilic C-2 lithio-species and substitution using an alkyl nucleophile. Arylation via unexpected sulfide contraction from the arylsulfenylation products has also been demonstrated. Taken with dihydroimidazole cleavage protocols, this constitutes a tetrahydrofolate-inspired C1-transfer protocol.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raymond C.F. Jones, John R. Nichols,