| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218307 | Tetrahedron | 2013 | 7 Pages |
Abstract
An efficient one-pot method for the synthesis of 2-sulfanyl-3-sulfinyl(or sulfonyl)-1H-indoles from 1-isothiocyanato-2-[sulfinyl(or sulfonyl)methyl]benzenes, derived from N-[2-(chloromethyl)phenyl]formamide by an easy four-step sequence, has been developed. The products are formed via cyclization of the precursor isothiocyanates using 2Â equiv of sodium hydride followed by S- and/or N-alkylation of the resulting 1-sodio-2-sodiosulfanyl-1H-indole intermediates.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![One-pot synthesis of 2-sulfanyl-3-sulfinyl(or sulfonyl)-1H-indoles via cyclization of 1-isothiocyanato-2-[sulfinyl(or sulfonyl)methyl]benzenes with sodium hydride](/preview/png/5218307.png "First Page Preview: One-pot synthesis of 2-sulfanyl-3-sulfinyl(or sulfonyl)-1H-indoles via cyclization of 1-isothiocyanato-2-[sulfinyl(or sulfonyl)methyl]benzenes with sodium hydride")
Authors
Kazuhiro Kobayashi, Akihiro Kobayashi, Kosuke Ezaki,