| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218319 | Tetrahedron | 2013 | 6 Pages |
Abstract
Simplified des-AB-type aglycone of antitumor steroidal saponin OSW-1 was concisely prepared starting from readily available Hajos ketone. We further completed the synthesis of des-AB-OSW-1 analogue by the installation of the disaccharide moiety into the des-AB aglycone, and evaluated its antitumor activity. The results indicated that a truncated aglycone drug design strategy based on OSW-1 would be a promising approach for the development of novel antitumor agents.
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Related Topics
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Organic Chemistry
Authors
Daishiro Minato, Bozhi Li, Dejun Zhou, Yasumi Shigeta, Naoki Toyooka, Hiroaki Sakurai, Kenji Sugimoto, Hideo Nemoto, Yuji Matsuya,