Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218326 | Tetrahedron | 2013 | 6 Pages |
The structure and relative/absolute configuration of the C-15:0 iso-branched fatty acyl 1,6-anhydropyranose 1 isolated from the Australian marine sponge Plakinastrella clathrata have been investigated. Synthesis of the C-16:0 side chain-modified analogues 3 and 4 has enabled the relative configuration of the C-3 lactate moiety to be secured. In a preliminary anti-inflammatory screening, glycolipid 1 exhibited moderate activity in a PGE2 inhibition assay, however, the compound showed no activity in cytotoxicity screening using 3T3 and P388 cell lines.
Graphical abstractDownload full-size imageThe structure, relative and absolute configuration of a glycolipid component 1 isolated from Plakinastrella clathrata have been confirmed by synthesis of analogues 3 and 4.