Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218340 | Tetrahedron | 2012 | 7 Pages |
Abstract
A new efficient and general synthetic methodology to access γ-aminothiols was investigated and developed. 1,3-Thiazines were used as convenient precursors and were prepared by a fast microwave-assisted three-component reaction (3CR) of thioamides, aldehydes, and alkenes. The transformation of thiazines into aminothiols was achieved via a thiazinium salt hydrolysis, in three very facile steps.
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