| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218365 | Tetrahedron | 2013 | 8 Pages |
Abstract
Total synthesis of prodelphinidin B3 and C2 have been accomplished. The key step is Lewis acid-mediated equimolar condensations between a catechin and/or gallocatechin nucleophile and a gallocatechin electrophile. The antitumor effects of synthetic prodelphidin B3 and C2 against PC-3 prostate cancer cell lines have been investigated. Both compounds showed significant antitumor effects. Their activity was almost the same as that of EGCG, a known antitumor agent.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wataru Fujii, Kazuya Toda, Koichiro Kawaguchi, Sei-ichi Kawahara, Miyuki Katoh, Yasunao Hattori, Hiroshi Fujii, Hidefumi Makabe,