Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218368 | Tetrahedron | 2013 | 6 Pages |
Abstract
A new strategy for the synthesis of l-3,4,5-trioxygenated phenylalanine derivatives from l-tyrosine is developed for the first time. The approach, featuring the transformation of aryl diiodide to bis-phenol via a one-pot procedure including lithiation, boronation, and oxidation, is highly practical. By this robust protocol, N-protected l-3,5-bis(tert-butyldimethylsilyloxy)-4-methoxy-phenylalanine and l-3,4,5-trimethoxy-phenylalanine derivatives were obtained from l-tyrosine in 9 steps with 36-40% overall yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ruijiao Chen, Hao Liu, Xiubing Liu, Xiaochuan Chen,