Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218385 | Tetrahedron | 2013 | 7 Pages |
Abstract
Atom transfer radical cyclization of N-(α-methyl)benzyl substituted trichloroacetamide upon α,β-unsaturated nitriles in compounds 1, using CuCl, trispyridylmethylamine (TPMA), and AIBN as a reducing agent, gives morphan derivatives (2 and 3) and the unusual normorphans 4 and 5, as well as the unexpected azaspirodecanes 6. Stereospecific formation of normorphans involves memory of chirality in the cyclization step and azaspirodecanes are generated by a radical dearomative ipsocyclization followed by a radical dimerization.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Faïza Diaba, Juan A. Montiel, Josep Bonjoch,