Article ID Journal Published Year Pages File Type
5218395 Tetrahedron 2013 9 Pages PDF
Abstract

A cascade process involving an SN2′ reaction and an intramolecular oxa-Michael addition has been developed by treating Morita–Baylis–Hillman acetates of nitroalkenes with arenols, such as β-naphthols, α-naphthols, and substituted phenols under basic conditions. The products, arenofurans, are formed as single regioisomers in good to excellent yield in most cases. The methodology has been successfully employed for the total synthesis of an anti fungal agent isoparvifuran.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry