Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218513 | Tetrahedron | 2012 | 6 Pages |
Abstract
Catalytic Mannich-type reactions of 9-fluorenylidene-protected α-aminoacetonitrile with imines were investigated. The desired reactions proceeded smoothly to afford the Mannich-type adducts in high yields with high diastereoselectivities in the presence of a catalytic amount of 1,1,3,3-tetramethylguanidine (TMG). A chiral guanidine catalyzed the reaction with good enantioselectivity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yasuhiro Yamashita, Masatoshi Matsumoto, Yi-Jing Chen, Shū Kobayashi,