Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218522 | Tetrahedron | 2012 | 6 Pages |
Abstract
An enzymatic kinetic resolution of diarylmethanols via acylation has been developed. This was achieved by the use of a mutated variant of CALB that accepts larger substrates compared to the wild type. By the use of diarylmethanols with two differently sized aryl groups, enantioselective transformations were achieved. A larger size-difference led to a higher enantioselectivity. In addition, substrates with electronically different aryl groups, such as phenyl and pyridyl, also gave an enantioselective reaction. The highest E value was observed with a substrate where steric and electronic effects were combined.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Karin Engström, Michaela Vallin, Karl Hult, Jan-E. Bäckvall,