| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218600 | Tetrahedron | 2013 | 7 Pages |
Abstract
A facile synthetic route toward functionalized 3-aryl-, 3,3′-diaryl-, 3,3′,5-triaryl-4,4′-dimethoxybiphenyls (polyphenyls) 3–5 with the terphenyl, quaterphenyl, quinquephenyl, and sexiphenyl skeleton starting from biphenyl-4,4′-diol (1) in modest total yield is described. The route has been carried by the two transformations of the regioselective NBS (N-bromosuccinimide)-mediated bromination of 2 in MeCN at reflux and Suzuki–Miyaura cross-coupling reaction of the resulting bromides with arylboronic acids 6 in DME at reflux.
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