Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218605 | Tetrahedron | 2013 | 6 Pages |
Abstract
Reductive acetylation of ketoximes to give the corresponding acyl enamides can be achieved by using 1-3 mol % of [RuCl2(p-cymene)]2 as the catalyst in the presence of KI as the reducing agent in high yields. This procedure has been applied to synthesize N-[1-(1,3-benzodioxol-5-yl)-1-butenyl]acetamide (6), which is the intermediate for the synthesis of DMP 777, an inhibitor of leukocyte elastase.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kaliyappan Murugan, Da-wei Huang, Yu-Ting Chien, Shiuh-Tzung Liu,