Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218610 | Tetrahedron | 2013 | 6 Pages |
Abstract
An efficient method for the preparation of unsymmetrical ethers from alcohols catalyzed by sodium bisulfite is reported. The procedure enables the direct dehydration of primary, secondary, and tertiary benzylic alcohols with aliphatic alcohols in the absence of solvent to selectively produce unsymmetrical ethers in high yields with low catalyst loading. No symmetrical ethers are generated in the reactions. The etherification of a chiral secondary benzyl alcohol with butanol exclusively yields racemic ethers, suggesting that the reaction involves a carbocation intermediate mechanism.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jun-Lai Yu, Hui Wang, Kai-Feng Zou, Jia-Rui Zhang, Xiang Gao, Dan-Wei Zhang, Zhan-Ting Li,