Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218612 | Tetrahedron | 2013 | 7 Pages |
Abstract
An efficient and facile catalytic protocol for benzoxazole-directed ortho-acylation of 2-arylbenzoxazoles has been described using aldehydes as the easily accessible acyl source. This catalytic system was performed in the presence of tert-butyl hydroperoxide (TBHP) as the oxidant in chlorobenzene, affording the acylated 2-arylbenzoxazoles in moderate to good yields. The acylation exhibited high regioselectivity for the substrates containing a meta-substituent in the benzene ring and typically occurred at the less sterically hindered ortho-C–H bond of the directing group.
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