Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218632 | Tetrahedron | 2013 | 6 Pages |
Abstract
Novel compounds bearing a joint thiazole and a Z-5-aminopent-3-enoic acid fragments have been synthesized from readily accessible 5-bromolevulinic esters through a sequence of nucleophilic substitution, bromination, Hantzsch-type heterocyclization and Gabriel-like deprotection reactions. A majority of these reactions proceed in ionic liquid media that enhances their efficiency and selectivity in comparison to the corresponding reactions in conventional organic solvents. The compounds have a significant pharmaceutical potential.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alexander G. Zavozin, Nikolai V. Ignat'ev, Michael Schulte, Sergei G. Zlotin,