Rare 2-phenylpyran-4-ones from the seagrass-derived fungi Polyporales PSU-ES44 and PSU-ES83

Eight new 2-phenylpyranon-4-one derivatives, polyporapyranones A-H (1-8), together with eight known compounds were isolated from two seagrass-derived fungi Polyporales PSU-ES44 and PSU-ES83. Their structures were determined by spectroscopic methods. 2-Phenylpyran-4-one derivatives are rare natural products. Some isolated compounds were evaluated for cytotoxic activity against human breast cancer (MCF-7) and noncancerous Vero (African green monkey kidney fibroblasts) cell lines.

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