Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218654 | Tetrahedron | 2013 | 6 Pages |
A new type of catalytic cascade reaction was found: the direct multicomponent transformation of acenaphthenequinone, cyclic ketones, and two molecules of malononitrile into spiroacenaphthylene pentacyclic systems. The fast (5Â min) reaction of acenaphthenequinone, cyclic ketones, and 2Â equiv of malononitrile at ambient temperature results in the formation of pentacyclic and pentaheterocyclic spiroacenaphthylene frameworks in 70-95% yields. Thus, a new simple fast and efficient 'one-pot' method to synthesize substituted spiroacenaphthylene frameworks was found directly from simple starting compounds. The application of this convenient multicomponent method is also beneficial from the viewpoint of diversity-oriented large-scale processes.
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