Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218743 | Tetrahedron | 2013 | 6 Pages |
Abstract
An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from isothiocyanates and hydrazides through cyclodesulfurization in the presence of (O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate) TBTU as an uronium coupling reagent has been developed. The present methodology offers several advantages, such as simple and easy work-up procedures, mild reaction conditions and it is environmentally benign.
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