| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218758 | Tetrahedron | 2013 | 6 Pages |
Abstract
The selective partial oxidation of small non-functionalized molecules using biocatalysis based on P450 monooxygenases is known to be difficult due to the expected poor regio- and stereoselectivity, but in this study it was nevertheless attempted. 1-Methylcyclohexene was subjected to oxygen-mediated biocatalytic oxidation using P450-BM3 as the catalyst. Both oxidative hydroxylation and epoxidation were observed, in some cases leading to hydroxy epoxides with high diastereo- and enantioselectivity especially when employing BM3 mutants.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gheorghe-Doru Roiban, Rubén Agudo, Manfred T. Reetz,