Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218837 | Tetrahedron | 2012 | 7 Pages |
Abstract
A straightforward solid phase-based strategy for the rapid generation of two small libraries of trans 3-alkyl-substituted β-lactams is described. For the glycine-derived library, a controlled excess of nonactivated acid chlorides was used to prevent oxazinone formation. The second library involved the attachment of Fmoc-protected p-aminophenol to Wang resin for the preparation of structurally-closed analogues of known cholesterol absorption inhibitors. This strategy allowed us to introduce diversity in the three variable positions of the β-lactam ring.
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Authors
Carina M.L. Delpiccolo, Sebastián A. Testero, Federico N. Leyes, Dora B. Boggián, Cristián M. Camacho, Ernesto G. Mata,