Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218878 | Tetrahedron | 2013 | 7 Pages |
Abstract
Four Ï1,Ï2-constrained cyclobutane-derived basic amino acids-conformationally restricted analogues of arginine, lysine and ornithine-were prepared as the derivatives properly protected for Fmoc-solid phase peptide synthesis. Compatibility of the synthesized arginine analogues with standard procedures of the Fmoc solid-phase peptide synthesis was demonstrated by incorporating these residues into the small cyclic antimicrobial peptide c-(RRRWFW) substituting the arginine residues. These replacements did not affect much the antimicrobial activity of the peptides.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dmytro S. Radchenko, Oleg M. Michurin, Oleksandr O. Grygorenko, Kathi Scheinpflug, Margitta Dathe, Igor V. Komarov,